Last week sometime we ran out of her Prilosec because I had spilled the bottle a few days after she started it. (I would have gotten a refill, but my shitty insurance wouldn't cover it 3 days early and that shit is $100+ out of pocket and it was a Sunday when we ran out and I didn't feel like going through the whole rigamarole with the on call pedi) We only missed her dose for 3 days, but man could you tell the difference. After day 2 of missing it she was fussy constantly, arching her back, puking more and just generally inconsolable. About 4 days after restarting, she was back to napping, less puking, no arching. My parents were here for the weekend and day 4 when the Prilosec fully kicked back in even my mom noticed a difference. I don't think its a fluke either, because it was day 4 or 5 that the Prilosec kicked in when we started it for the very first time.
I've also noticed a difference if she doesn't have the medicine first thing in the morning. A few times I haven't remembered to give it to her until the afternoon, and I've noticed that she is definitely more fussy. The hard part is trying to time her dosing on an empty stomach. Usually she isn't completely "empty", but I do try to not feed her immediately before or after.
She still gets hiccups multiple times per day, almost 20-30 minutes after eating without fail. There has to be some biologic reason for it, but I have no idea what. I've never known someone to get hiccups like 5 times per day. It just seems weird. We give her gripe water when they start which stops them, because if we don't she gulps in a lot of air and then gets gassy and uncomfortable. Sometimes if she's having a particularly bad day, she'll get a shot of gripe water with a chaser of Mylicon. It's a cocktail I like to call "The Sadie" ;)
She still pukes a lot, but when she has her medicine its a lot less forceful - meaning it doesn't shoot out her nose as well. When my sister Kellie was little she was a puker too, and my parents called her "The Spew Monster" for a while. Well, Sadie is taking after her Auntie and is a Spew Monster as well :)
So, all in all, things are pretty much under control when it comes to the reflux, I just hope it stays this way and she grows out of needing the meds at some point :)